Spread of premalignant mutant clones and cancer initiation in multilayered tissue
Spread of premalignant mutant clones and cancer initiation in multilayered tissue
Over 80% of human cancers originate from the epithelium, which covers the outer and inner surfaces of organs and blood vessels. In stratified epithelium, the bottom layers are occupied by stem and stem-like cells that continually divide and replenish the upper layers. In this work, we study the spread of …