Stakeholder perspectives on adaptive clinical trials: a scoping review
Stakeholder perspectives on adaptive clinical trials: a scoping review
Abstract Background Adaptive clinical trials (ACTs) represent an emerging approach to trial design where accumulating data are used to make decisions about future conduct. Adaptations can include comparisons of multiple dose tiers, response-adaptive randomization, sample size re-estimation, and efficacy/futility stopping rules. The objective of this scoping review is to assess …