Assurance for clinical trial design with normally distributed outcomes: Eliciting uncertainty about variances
Assurance for clinical trial design with normally distributed outcomes: Eliciting uncertainty about variances
Summary The assurance method is growing in popularity in clinical trial planning. The method involves eliciting a prior distribution for the treatment effect, and then calculating the probability that a proposed trial will produce a “successful” outcome. For normally distributed observations, uncertainty about the variance of the normal distribution also …