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Impact of blinding on estimated treatment effects in randomised clinical trials: meta-epidemiological study

Impact of blinding on estimated treatment effects in randomised clinical trials: meta-epidemiological study

Abstract Objectives To study the impact of blinding on estimated treatment effects, and their variation between trials; differentiating between blinding of patients, healthcare providers, and observers; detection bias and performance bias; and types of outcome (the MetaBLIND study). Design Meta-epidemiological study. Data source Cochrane Database of Systematic Reviews (2013-14). Eligibility …