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Epigenetic Ratchet: Spontaneous Adaptation via Stochastic Gene Expression

Epigenetic Ratchet: Spontaneous Adaptation via Stochastic Gene Expression

Abstract Adaptation to unforeseen environmental changes is one of the most prominent features that characterize the living system. Although signal transduction and gene regulation networks evolved to adapt specific environmental conditions that they frequently experience, it is also reported that bacteria can modify their gene expression patterns to survive a …