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Incorporating human and learned domain knowledge into training deep neural networks: A differentiable dose‐volume histogram and adversarial inspired framework for generating Pareto optimal dose distributions in radiation therapy

Incorporating human and learned domain knowledge into training deep neural networks: A differentiable dose‐volume histogram and adversarial inspired framework for generating Pareto optimal dose distributions in radiation therapy

We propose a novel domain specific loss, which is a differentiable loss function based on the dose volume histogram, and combine it with an adversarial loss for the training of deep neural networks to generate Pareto optimal dose distributions. The mean squared error (MSE) loss, dose volume histogram (DVH) loss, …