ASIED: a Bayesian adaptive subgroup-identification enrichment design
ASIED: a Bayesian adaptive subgroup-identification enrichment design
Developing targeted therapies based on patients' baseline characteristics and genomic profiles such as biomarkers has gained growing interests in recent years. Depending on patients' clinical characteristics, the expression of specific biomarkers or their combinations, different patient subgroups could respond differently to the same treatment. An ideal design, especially at the …