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Active interfacial dynamic transport of fluid in fibrous connective tissues and a hypothesis of interstitial fluid circulatory system
Fluid in interstitial spaces accounts for ~20% of an adult body weight. Does it circulate around the body like vascular circulations besides a diffusive and short-ranged transport? This bold conjecture has been debated for decades. As a conventional physiological concept, interstitial space was the space between cells and a micron-sized …