Single-cell stochastic gene expression kinetics with coupled positive-plus-negative feedback
Single-cell stochastic gene expression kinetics with coupled positive-plus-negative feedback
Here we investigate single-cell stochastic gene expression kinetics in a minimal coupled gene circuit with positive-plus-negative feedback. A triphasic stochastic bifurcation is observed upon increasing the ratio of the positive and negative feedback strengths, which reveals a strong synergistic interaction between positive and negative feedback loops. We discover that coupled …