Inferring Tumor Proliferative Organization from Phylogenetic Tree Measures in a Computational Model
Inferring Tumor Proliferative Organization from Phylogenetic Tree Measures in a Computational Model
We use a computational modeling approach to explore whether it is possible to infer a solid tumor's cellular proliferative hierarchy under the assumptions of the cancer stem cell hypothesis and neutral evolution. We work towards inferring the symmetric division probability for cancer stem cells, since this is believed to be …