Leveraging transcriptional dynamics to improve BRAF inhibitor responses in melanoma
Leveraging transcriptional dynamics to improve BRAF inhibitor responses in melanoma
Melanoma is a heterogeneous tumour, but the impact of this heterogeneity upon therapeutic response is not well understood.Single cell mRNA analysis was used to define the transcriptional heterogeneity of melanoma and its dynamic response to BRAF inhibitor therapy and treatment holidays. Discrete transcriptional states were defined in cell lines and …