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The Narrow Escape Problem in a Flat Cylindrical Microdomain with Application to Diffusion in the Synaptic Cleft
The mean first passage time (MFPT) for a Brownian particle to reach a small target in cellular microdomains is a key parameter for chemical activation. Although asymptotic estimations of the MFPT are available for various geometries, these formulas cannot be applied to degenerated structures where one dimension is much smaller …