Covariance Matrix Estimation for the Cryo-EM Heterogeneity Problem
Covariance Matrix Estimation for the Cryo-EM Heterogeneity Problem
In cryo-electron microscopy (cryo-EM), a microscope generates a top view of a sample of randomly oriented copies of a molecule. The problem of single particle reconstruction (SPR) from cryo-EM is to use the resulting set of noisy two-dimensional projection images taken at unknown directions to reconstruct the three-dimensional (3D) structure …