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Mechanism of Thermal Renaturation and Hybridization of Nucleic Acids: Kramers’ Process and Universality in Watson−Crick Base Pairing
Renaturation and hybridization reactions lead to the pairing of complementary single-stranded nucleic acids. We present here a theoretical investigation of the mechanism of these reactions in vitro under thermal conditions (dilute solutions of single-stranded chains, in the presence of molar concentrations of monovalent salts and at elevated temperatures). The mechanism …