3D ab initio modeling in cryo-EM by autocorrelation analysis
3D ab initio modeling in cryo-EM by autocorrelation analysis
Single-Particle Reconstruction (SPR) in Cryo-Electron Microscopy (cryo-EM) is the task of estimating the 3D structure of a molecule from a set of noisy 2D projections, taken from unknown viewing directions. Many algorithms for SPR start from an initial reference molecule, and alternate between refining the estimated viewing angles given the …