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Adaptive propensity score procedure improves matching in prospective observational trials

Adaptive propensity score procedure improves matching in prospective observational trials

Randomized controlled trials are the gold-standard for clinical trials. However, randomization is not always feasible. In this article we propose a prospective and adaptive matched case-control trial design assuming that a control group already exists.We propose and discuss an interim analysis step to estimate the matching rate using a resampling …