A filter-flow perspective of hematogenous metastasis offers a non-genetic paradigm for personalized cancer therapy
A filter-flow perspective of hematogenous metastasis offers a non-genetic paradigm for personalized cancer therapy
Background: Research into mechanisms of hematogenous metastasis has largely become genetic in focus, attempting to understand the molecular basis of `seed-soil' relationships. However, preceding this biological mechanism is the physical process of dissemination of circulating tumour cells (CTCs) in the circulatory network. We utilize a novel, network perspective of hematogenous …