Toward understanding cancer stem cell heterogeneity in the tumor microenvironment
Toward understanding cancer stem cell heterogeneity in the tumor microenvironment
Significance The presence of heterogeneous subsets of cancer stem cells (CSCs) remains a clinical challenge. These subsets often occupy different regions in the primary tumor and have varied epithelial–mesenchymal phenotypes. Here, we devise a theoretical framework to investigate how the tumor microenvironment (TME) modulates this spatial patterning. We find that …