OLGA: fast computation of generation probabilities of B- and T-cell receptor amino acid sequences and motifs
OLGA: fast computation of generation probabilities of B- and T-cell receptor amino acid sequences and motifs
Motivation: High-throughput sequencing of large immune repertoires has enabled the development of methods to predict the probability of generation by V(D)J recombination of T- and B-cell receptors of any specific nucleotide sequence. These generation probabilities are very non-homogeneous, ranging over 20 orders of magnitude in real repertoires. Since the function …