THE INEVITABILITY OF UNCONDITIONALLY DELETERIOUS SUBSTITUTIONS DURING ADAPTATION
THE INEVITABILITY OF UNCONDITIONALLY DELETERIOUS SUBSTITUTIONS DURING ADAPTATION
Studies on the genetics of adaptation typically neglect the possibility that a deleterious mutation might fix. Nonetheless, here we show that, in many regimes, the first substitution is most often deleterious, even when fitness is expected to increase in the long term. In particular, we prove that this phenomenon occurs …