Effect Estimates in Randomized Trials and Observational Studies: Comparing Apples With Apples
Effect Estimates in Randomized Trials and Observational Studies: Comparing Apples With Apples
Abstract Effect estimates from randomized trials and observational studies might not be directly comparable because of differences in study design, other than randomization, and in data analysis. We propose a 3-step procedure to facilitate meaningful comparisons of effect estimates from randomized trials and observational studies: 1) harmonization of the study …