A Mechanism for Epithelial-Mesenchymal Heterogeneity in a Population of Cancer Cells
A Mechanism for Epithelial-Mesenchymal Heterogeneity in a Population of Cancer Cells
Summary Epithelial-mesenchymal heterogeneity, wherein cells within the same tumor can exhibit an epithelial, a mesenchymal, or one or more hybrid epithelial-mesenchymal phenotype(s), has been observed across cancer types and implicated in metastatic aggressiveness. Here, we have used computational modeling to show that this heterogeneity can emerge from the noise in …