Modeling differentiation-state transitions linked to therapeutic escape in triple-negative breast cancer
Modeling differentiation-state transitions linked to therapeutic escape in triple-negative breast cancer
Drug resistance in breast cancer cell populations has been shown to arise through phenotypic transition of cancer cells to a drug-tolerant state, for example through epithelial-to-mesenchymal transition or transition to a cancer stem cell state. However, many breast tumors are a heterogeneous mixture of cell types with numerous epigenetic states …