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Radiation resistant cancer cells enhance the survival and resistance of sensitive cells in prostate spheroids

Radiation resistant cancer cells enhance the survival and resistance of sensitive cells in prostate spheroids

ABSTRACT Intratumoural heterogeneity contributes to local tumour recurrence and variable responses to radiotherapy in prostate cancer. Despite the multiclonal nature of the disease, tumour control probability for conventional treatment plans is modelled on the assumption that tumour cells in the target region respond identically and independently. Here, using tumour cell …