The harmonic mean <i>p</i> -value for combining dependent tests
The harmonic mean <i>p</i> -value for combining dependent tests
Analysis of "big data" frequently involves statistical comparison of millions of competing hypotheses to discover hidden processes underlying observed patterns of data, for example, in the search for genetic determinants of disease in genome-wide association studies (GWAS). Controlling the familywise error rate (FWER) is considered the strongest protection against false …