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‘Optimism bias’ in contemporary national clinical trial network phase III trials: are we improving?
BackgroundPrevious studies have found that overestimating treatment effects (i.e. 'optimism bias') leads to underpowered clinical trials. The prevalence of 'optimism bias' in contemporary National Clinical Trials Network (NCTN) cancer clinical trials is unknown.MethodsWe conducted a systematic review of NCTN phase III randomized trials published from January 2007 to January 2017. …