Interim Futility Monitoring Assessing Immune Therapies With a Potentially Delayed Treatment Effect
Interim Futility Monitoring Assessing Immune Therapies With a Potentially Delayed Treatment Effect
Purpose Introduction of new immune therapies that may have a delayed beneficial effect necessitates re-evaluation of traditional clinical trial designs in oncology. A key design feature of randomized trials is interim futility monitoring, which allows stopping early if the accruing data convincingly demonstrate that the experimental treatment is detrimental or …