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Bayesian selective response‐adaptive design using the historical control

Bayesian selective response‐adaptive design using the historical control

High quality historical control data, if incorporated, may reduce sample size, trial cost, and duration. A too optimistic use of the data, however, may result in bias under prior‐data conflict. Motivated by well‐publicized two‐arm comparative trials in stroke, we propose a Bayesian design that both adaptively incorporates historical control data …