Inferring Tumour Proliferative Organisation from Phylogenetic Tree Measures in a Computational Model
Inferring Tumour Proliferative Organisation from Phylogenetic Tree Measures in a Computational Model
ABSTRACT We use a computational modelling approach to explore whether it is possible to infer a tumour’s cell proliferative hierarchy, under the assumptions of the cancer stem cell hypothesis and neutral evolution. We focus on inferring the symmetric division probability for cancer stem cells in our model, as this is …