Design and inference for 3‐stage bioequivalence testing with serial sampling data
Design and inference for 3‐stage bioequivalence testing with serial sampling data
A bioequivalence test is to compare bioavailability parameters, such as the maximum observed concentration (Cmax ) or the area under the concentration-time curve, for a test drug and a reference drug. During the planning of a bioequivalence test, it requires an assumption about the variance of Cmax or area under …