Mathematical modeling of tumor-associated macrophage interactions with the cancer microenvironment
Mathematical modeling of tumor-associated macrophage interactions with the cancer microenvironment
<h3>Background</h3> Immuno-oncotherapy has emerged as a promising means to target cancer. In particular, therapeutic manipulation of tumor-associated macrophages holds promise due to their various and sometimes opposing roles in tumor progression. It is established that M1-type macrophages suppress tumor progression while M2-types support it. Recently, Tie2-expressing macrophages (TEM) have been …