Radiation and PD-(L)1 treatment combinations: immune response and dose optimization via a predictive systems model
Radiation and PD-(L)1 treatment combinations: immune response and dose optimization via a predictive systems model
<h3>Background</h3> Numerous oncology combination therapies involving modulators of the cancer immune cycle are being developed, yet quantitative simulation models predictive of outcome are lacking. We here present a model-based analysis of tumor size dynamics and immune markers, which integrates experimental data from multiple studies and provides a validated simulation framework …