Adaptive design clinical trials: a review of the literature and ClinicalTrials.gov
Adaptive design clinical trials: a review of the literature and ClinicalTrials.gov
This review investigates characteristics of implemented adaptive design clinical trials and provides examples of regulatory experience with such trials.Review of adaptive design clinical trials in EMBASE, PubMed, Cochrane Registry of Controlled Clinical Trials, Web of Science and ClinicalTrials.gov. Phase I and seamless Phase I/II trials were excluded. Variables extracted from …