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ERDO - a framework to select an appropriate randomization procedure for clinical trials

ERDO - a framework to select an appropriate randomization procedure for clinical trials

Randomization is considered to be a key feature to protect against bias in randomized clinical trials. Randomization induces comparability with respect to known and unknown covariates, mitigates selection bias, and provides a basis for inference. Although various randomization procedures have been proposed, no single procedure performs uniformly best. In the …