Optimization of spatiotemporally fractionated radiotherapy treatments with bounds on the achievable benefit
Optimization of spatiotemporally fractionated radiotherapy treatments with bounds on the achievable benefit
Spatiotemporal fractionation schemes, that is, treatments delivering different dose distributions in different fractions, may lower treatment side effects without compromising tumor control. This is achieved by hypofractionating parts of the tumor while delivering approximately uniformly fractionated doses to the healthy tissue. Optimization of such treatments is based on biologically effective …