The evolution of tumour composition during fractionated radiotherapy: implications for outcome
The evolution of tumour composition during fractionated radiotherapy: implications for outcome
Abstract Current protocols for delivering radiotherapy are based primarily on tumour stage and nodal and metastases status, even though it is well known that tumours and their microenvironments are highly heterogeneous. It is well established that the local oxygen tension plays an important role in radiation-induced cell death, with hypoxic …