Cell adhesion heterogeneity reinforces tumour cell dissemination: novel insights from a mathematical model
Cell adhesion heterogeneity reinforces tumour cell dissemination: novel insights from a mathematical model
Cancer cell invasion, dissemination, and metastasis have been linked to an epithelial-mesenchymal transition (EMT) of individual tumour cells. During EMT, adhesion molecules like E-cadherin are downregulated and the decrease of cell-cell adhesion allows tumour cells to dissociate from the primary tumour mass. This complex process depends on intracellular cues that …