Many-to-one comparisons after safety selection in multi-arm clinical trials
Many-to-one comparisons after safety selection in multi-arm clinical trials
In phase II platform trials, 'many-to-one' comparisons are performed when K experimental treatments are compared with a common control to identify the most promising treatment(s) to be selected for Phase III trials. However, when sample sizes are limited, such as when the disease of interest is rare, only a single …