Comparing performances of several response-adaptive designs in dose finding studies
Comparing performances of several response-adaptive designs in dose finding studies
The main objectives of dose-finding studies are (i) to select the best dose(s) for future phase 3 and/or (ii) to evaluate the dose-response relationship. At that phase 2B stage of the drug development, little is known about the drug's efficacy, and only a small- to moderate-size sample can be experimented. …