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We present an observation and time-integrated rate measurement of the decay ${D}^{0}\ensuremath{\rightarrow}{K}^{+}{\ensuremath{\pi}}^{\ensuremath{-}}{\ensuremath{\pi}}^{0}$ produced in $9{\mathrm{fb}}^{\ensuremath{-}1}$ of ${e}^{+}{e}^{\ensuremath{-}}$ collisions near the $\ensuremath{\Upsilon}(4S)$ resonance. The signal is inconsistent with an upward fluctuation of the background by 4.9 standard deviations. We measured the time-integrated rate of ${D}^{0}\ensuremath{\rightarrow}{K}^{+}{\ensuremath{\pi}}^{\ensuremath{-}}{\ensuremath{\pi}}^{0}$ normalized to the rate of $\overline{{D}^{0}}\ensuremath{\rightarrow}{K}^{+}{\ensuremath{\pi}}^{\ensuremath{-}}{\ensuremath{\pi}}^{0}$ …