Computationally Discovered Potentiating Role of Glycans on NMDA Receptors
Computationally Discovered Potentiating Role of Glycans on NMDA Receptors
Abstract N-methyl-D-aspartate receptors (NMDARs) are glycoproteins in the brain central to learning and memory. The effects of glycosylation on the structure and dynamics of NMDARs are largely unknown. In this work, we use extensive molecular dynamics simulations of GluN1 and GluN2B ligand binding domains (LBDs) of NMDARs to investigate these …