Biomarker-Guided Non-Adaptive Trial Designs in Phase II and Phase III: A Methodological Review
Biomarker-Guided Non-Adaptive Trial Designs in Phase II and Phase III: A Methodological Review
Biomarker-guided treatment is a rapidly developing area of medicine, where treatment choice is personalised according to one or more of an individual’s biomarker measurements. A number of biomarker-guided trial designs have been proposed in the past decade, including both adaptive and non-adaptive trial designs which test the effectiveness of a …