Set-Based Tests for the Gene–Environment Interaction in Longitudinal Studies
Set-Based Tests for the Gene–Environment Interaction in Longitudinal Studies
We propose a generalized score type test for set-based inference for gene-environment interaction with longitudinally measured quantitative traits. The test is robust to misspecification of within subject correlation structure and has enhanced power compared to existing alternatives. Unlike tests for marginal genetic association, set-based tests for gene-environment interaction face the …