Parameter Identifiability of Fundamental Pharmacodynamic Models
Parameter Identifiability of Fundamental Pharmacodynamic Models
Issues of parameter identifiability of routinely used pharmacodynamics models are considered in this paper. The structural identifiability of 16 commonly applied pharmacodynamic model structures was analysed analytically, using the input-output approach. Both fixed-effects versions (non-population, no between-subject variability) and mixed-effects versions (population, including between-subject variability) of each model structure were …