The role of the Hes1 crosstalk hub in Notch-Wnt interactions of the intestinal crypt
The role of the Hes1 crosstalk hub in Notch-Wnt interactions of the intestinal crypt
The Notch pathway plays a vital role in determining whether cells in the intestinal epithelium adopt a secretory or an absorptive phenotype. Cell fate specification is coordinated via Notch's interaction with the canonical Wnt pathway. Here, we propose a new mathematical model of the Notch and Wnt pathways, in which …