Systems-level approach to uncovering diffusive states and their transitions from single-particle trajectories
Systems-level approach to uncovering diffusive states and their transitions from single-particle trajectories
The stochastic motions of a diffusing particle contain information concerning the particle's interactions with binding partners and with its local environment. However, accurate determination of the underlying diffusive properties, beyond normal diffusion, has remained challenging when analyzing particle trajectories on an individual basis. Here, we introduce the maximum likelihood estimator …