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A Bayesian multivariate joint frailty model for disease recurrences and survival

A Bayesian multivariate joint frailty model for disease recurrences and survival

Motivated by a study for soft tissue sarcoma, this article considers the analysis of diseases recurrence and survival. A multivariate frailty hazard model is established for joint modeling of three correlated time-to-event outcomes: local disease recurrence, distant disease recurrence (metastasis), and death. The goals are to find out (i) the …