Ligand–receptor binding kinetics in surface plasmon resonance cells: a Monte Carlo analysis
Ligand–receptor binding kinetics in surface plasmon resonance cells: a Monte Carlo analysis
Surface plasmon resonance (SPR) chips are widely used to measure association and dissociation rates for the binding kinetics between two species of chemicals, e.g., cell receptors and ligands. It is commonly assumed that ligands are spatially well mixed in the SPR region, and hence a mean-field rate equation description is …