Persisting fetal clonotypes influence the structure and overlap of adult human T cell receptor repertoires
Persisting fetal clonotypes influence the structure and overlap of adult human T cell receptor repertoires
The diversity of T-cell receptors recognizing foreign pathogens is generated through a highly stochastic recombination process, making the independent production of the same sequence rare. Yet unrelated individuals do share receptors, which together constitute a "public" repertoire of abundant clonotypes. The TCR repertoire is initially formed prenatally, when the enzyme …