Targeting adaptive glioblastoma: an overview of proliferation and invasion
Targeting adaptive glioblastoma: an overview of proliferation and invasion
Glioblastoma is one of the most devastating cancers, in which tumor cell infiltration into surrounding normal brain tissue confounds clinical management. This review describes basic and translational research into glioma proliferation and invasion, in particular the phenotypic switch underlying a stochastic "go or grow" model of tumor cell behavior. We …